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The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). Allopurinol will help prevent gout attacks only as long as you continue to take it. In one study in mice, large amounts of allopurinol caused birth defects and other unwanted effects. A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. Ask your health care provider if Allopurinol may interact with other medicines that you take.

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