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If you are or will be breast-feeding while you use Allopurinol , check with your doctor. However, allopurinol did not cause birth defects or other problems in rats or rabbits given doses up to 20 times the amount usually given to humans. There are no data with Augmentin and allopurinol administered concurrently. After you have been taking allopurinol regularly for several months, the attacks may stop completely. This pathway of Thioguanine inactivation is not dependent on the action of xanthine oxidase, and an inhibitor of that enzyme (such as allopurinol) will not block the detoxification of Thioguanine even though the inactive 6-thioxanthine is normally further oxidized by xanthine oxidase to thiouric acid before it is eliminated. The total amount of allopurinol is usually not more than 800 mg a day.
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