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In the case of Avandia, researchers focused on the durability of the patients' blood sugar control ("glycemic durability"), even though blood sugar control is "a relatively poor surrogate for cardiovascular outcomes in type 2 diabetes," Rosen said. Clifford Rosen, of the Maine Center for Osteoporosis, who headed the recent FDA advisory committee panel that recommended Avandia stay on the market, albeit with stronger warnings. Lavie, medical director for cardiac rehabilitation and prevention director of the Stress Testing Laboratory at the Ochsner Heart and Vascular Institute in New Orleans, thinks the study gives more reasons not to use Avandia. The FDA has requested that Avandia's maker, GlaxoSmithKline, strengthen its warning about heart-failure risk. Initiation of Avandia in patients with established NYHA Class III or IV heart failure is contraindicated.
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